The Cardioprotective Effect of Necrostatin Requires the Cyclophilin-D Component of the Mitochondrial Permeability Transition Pore
- 27 October 2007
- journal article
- research article
- Published by Springer Nature in Cardiovascular Drugs and Therapy
- Vol. 21 (6) , 467-469
- https://doi.org/10.1007/s10557-007-6067-6
Abstract
Necrostatin (Nec-1) protects against ischemia–reperfusion (IR) injury in both brain and heart. We have previously reported in this journal that necrostatin can delay opening of the mitochondrial permeability transition pore (MPTP) in isolated cardiomyocytes.Keywords
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