Microcirculatory Changes in the Liver of Choline-Deficient Rats.

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Abstract
Weanling rats fed a choline-deficient diet accumulate fat within 1 to 2 days in zone 3 of the "liver acinus". This zone lies farthest from the terminal portal and hepatic arterial branches. Hepatic transillumination in vivo was helped by the use of a plastic apron closing the abdominal cavity in which the pressure was raised by instilled Ringer''s solution. The control of the pressure gradient between thoracic and peritoneal cavities permitted liver immobilization and observation of its circulation for hours. From the first day tiny fat globules appeared in the hepatocytes close to the sinusoids; they increased in number and size and indented the walls of the sinusoids, impeding blood flow.

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