The Influence of Heparin on the Course of Anaphylaxis in the Guinea Pig

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Abstract
A decreased coagulability of the blood of the experimental animal during anaphylactic shock has been observed in dogs (1), rabbits (2), guinea pigs (3), and more recently in pigeons (4), (5). This is perhaps most pronounced in the dog (2), although very definite in the other animals mentioned. Few attempts have been made to correlate this phenomenon with the progress of anaphylactic shock. It is the purpose of this paper to report the results obtained when an anticoagulant, heparin, is used to increase the coagulation time of the blood of a sensitized animal before the shock dose of antigen is injected. In a previous communication (6) it was shown that repeated injections of heparin after suitable intervals did not produce any anaphylactic symptoms in guinea pigs. It was also mentioned that the power of heparin to modify the anaphylactic reaction from horse serum was then under investigation.

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