Intra-arterial Dye Method with Vasomotors (PIAD Method) Applied for the Endoscopic Diagnosis of Gastric Cancer and the Side Effects of Indigo Carmine

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Abstract
Forty patients with stomach cancer, including 25 patients with early carcinoma, were examined endoscopically during the perfusion of Indigo carmine dye into the celiac artery in association with vasomotors. In all of these patients the diagnosis had been established definitively by aimed biopsies before the procedure. This new endoscopic examination is useful not only to determine the margin of the superficial carcinoma, even when it is covered with regenerative epithelium, but also to detect small lesion less than 10 mm in diameter. Liver function tests in 31 patients who underwent the examination have negated the possibility of acute toxicity of the dye. But this new method should be employed with caution in hypertensive or high-risk patients.

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