Porcine pituitary dynorphin: complete amino acid sequence of the biologically active heptadecapeptide.
- 1 November 1981
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 78 (11) , 7219-7223
- https://doi.org/10.1073/pnas.78.11.7219
Abstract
The full primary structure of the very potent opioid peptide dynorphin, from porcine pituitary, was determined. It is (H)Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln(OH). The synthetic peptide with this sequence behaves identically to natural dynorphin in a number of ways, and it has the same potency in the guinea pig ileum myenteric plexus-longitudinal muscle bioassay. The potency is accounted for by the 1st 13 residues.Keywords
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