Restoration of specific immunity against SV40 tumor‐specific transplantation antigen to lymphoid cells from tumor‐bearing mice

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Abstract
Specific cell‐mediated immunity to SV40 tumor‐specific transplantation antigen (TSTA) in BALB/c mice undergoing progressive tumorigenesis by syngeneic SV40‐transformed cells (VLM) was investigated in vivo using a tumor‐cell neutralization test. Specific cellular reactivity to SV40 TSTA was not detected in BALB/c mice bearing large tumors (10‐15 mm mean diameter) but was demonstrable after tumor excision. Specific cytotoxic reactivity against syngeneic SV40‐transformed cells in vivo could be restored to lymphoid cells from VLM tumor‐bearing mice either by culturing the lymphoid cells in vitro or by treating them with papain or trypsin. Enzyme‐treated lymphoid cells from MCA tumor‐bearing BALB/c mice had no cytotoxic reactivity against VLM cells. These studies suggest that tumor‐bearing hosts possess lymphocytes which are sensitized to the TSTA of the tumor but that the reactivity of these lymphocytes is blocked.

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