Effects of D600 on hypoxic suppresssion of K+ currents in isolated type I carotid body cells of the neonatal rat
Open Access
- 1 October 1990
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 271 (1-2) , 37-40
- https://doi.org/10.1016/0014-5793(90)80366-q
Abstract
K+ currents recorded from isolated type I carotid body cells were reversibly suppressed by hypoxia (pO2 25 Torr). Inhibition of Ca2+ influx using high Mg2+, low Ca2+ solutions abolished this effect, indicating hypoxia selectively inhibits the Ca2+‐activa ted component of K+ currents. The Ca2+ channel blockers D600 and verapamil reversed the suppressive effects of hypoxia. These drugs also partially inhibited Ca2+‐independent K+ currents, but this effect was relieved by hypoxia, causing apparent reversal of hypoxic suppression of the K+ currents seen under control conditions.Keywords
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