Deduced primary structure of the alpha subunit of the GTP-binding stimulatory protein of adenylate cyclase.
- 1 March 1986
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 83 (5) , 1251-1255
- https://doi.org/10.1073/pnas.83.5.1251
Abstract
A bovine adrenal cDNA clone encoding the entire .alpha. subunit of the GTP-binding regulatory protein that stimulates adenylate cyclase (Gs) was isolated and sequenced. This cDNA directed the synthesis of the larger, 52-kDa form of the polypeptide in COS cells, even though the clone appeared to encode a 46-kDa protein. Comparison of the deduced amino acid sequence of Gs.alpha. with the .alpha. subunit of another G protein, transducin, revealed striking homologies.This publication has 42 references indexed in Scilit:
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