Syngeneic sensitization of mouse lymphocytes on monolayers of thyroid epithelial cells:

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Abstract
The determination of the frequency of normal spleen cell involvement in primary syngeneic sensitization (PSS) against thyroid epithelial cells (TEC) was performed using the limiting dilution analysis. Their frequency, which reaches 1:5440, is related to the expression of major histocompatibility complex (MHC) antigens (K end or D end) and to the specific antigen thyroglobulin (Tg) exposed on the surface of the TEC monolayer. A significant diminution of this frequency was obtained by the addition of 25% normal syngeneic lymph node (LN) cells.