Content of significant amounts of a cytotoxic end-product of lipid peroxidation in human semen

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Abstract
Summary. (E)-4-Hydroxy-2-nonenal (HNE), a cytotoxic end-product of lipid peroxidation, is present in significant amounts in human semen (0·902 ± 0·190μm; mean ± s.e.; n = 18). The addition of the divalent cation ionophore A23187 to suspensions of human spermatozoa resulted in increased production of HNE. Exogenous HNE was powerfully spermicidal and as little as 50μm caused an irreversible loss of motility of human spermatozoa within minutes. The addition of human seminal plasma protected spermatozoa from the toxic effects of HNE. Keywords: (E)-4-Hydroxy-2-nonenal; lipid peroxidation; cytotoxicity; human seminal plasma

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