Hormonal Intervention In The Uptake Of Amino Acids By Staphylococci
- 1 February 1971
- journal article
- Published by Microbiology Society in Journal of Medical Microbiology
- Vol. 4 (1) , 89-96
- https://doi.org/10.1099/00222615-4-1-89
Abstract
Hormonal effects on the uptake of amino acids by Staphylococcus aureus have been studied in relation to the reported antibacterial action of the hormones. Progesterone at 40 μg per ml retarded the uptake of 14C-alanine and 14C-glutamic acid. Diethylstilboestrol, testosterone and oestradiol-17β exerted similar inhibitory effects, whereas 17α-hydroxyprogesterone did not. Maximum inhibition of alanine uptake occurred at a cellular density corresponding to 260 μg dry weight per ml, at a pH value between 5·7 and 7·0, and with diethylstilboestrol at a concentration of 20 μg per ml. The assimilation of alanine by Shigella flexneri and Salmonella paratyphi was not inhibited by progesterone. The data are correlated with inhibitory phenomena previously observed and indicate parameters for further research toward elucidation of the hormonal mechanism of inhibition of Staph. aureus.Keywords
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