Ethanol Potentiates the Toxic Effects of 1,4‐Butanediol
- 1 November 1985
- journal article
- research article
- Published by Wiley in Alcohol, Clinical and Experimental Research
- Vol. 9 (6) , 493-497
- https://doi.org/10.1111/j.1530-0277.1985.tb05589.x
Abstract
The simultaneous administration of ethanol increases the mortality rate and tissue damage observed in rats after 1,4‐butanediol (1,4‐BO). A related increase in tissue 1,4‐BO concentration supported the hypothesis of an in vivo competition of the two substances for alcohol dehydrogenase. The clinical implications of the results, in light of the recent discovery of the presence of endogenous 1,4‐BD in humans are discussed.This publication has 20 references indexed in Scilit:
- 1,4 Butanediol, γ-hydroxybutyric acid and ethanol: Relationships and interactionsNeuropharmacology, 1984
- Subcutaneous silastic implants: Maintenance of high blood ethanol levels in rats drinking a liquid dietPharmacology Biochemistry and Behavior, 1980
- Alcohol dehydrogenase from human and horse liver—Substrate specificity with diolsBiochemical Pharmacology, 1978
- Haloperidol-induced tolerance to morphine catalepsyLife Sciences, 1977
- Induction of physical dependence upon ethanol and the associated behavioral changes in ratsPsychopharmacology, 1975
- 1,4-butanediol—A substrate for rat liver and horse liver alcohol dehydrogenasesBiochemical Pharmacology, 1972
- Metabolic factors involved in the interaction between pyrazole and butane-1, 4-diol and 4-hydroxybutyric acidLife Sciences, 1972
- Microdetermination of alcohol in blood by gas–liquid chromatographyCanadian Journal of Physiology and Pharmacology, 1968
- Histochemical Distribution of Alcohol Dehydrogenases in Endocrine TissueNature, 1966
- Studies in detoxication. 80. The metabolism of glycolsBiochemical Journal, 1960