Comparative activities of UK-49,858 and amphotericin B against Blastomyces dermatitidis infections in mice
Open Access
- 1 January 1986
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 29 (1) , 161-162
- https://doi.org/10.1128/aac.29.1.161
Abstract
UK-49,858, a new antifungal triazole derivative, was compared with amphotericin B in the treatment of pulmonary infections by Blastomyces dermatitidis in male BALB/cByJ mice. Administration of UK-49,858 in daily doses of 25 or 50 mg/kg for 21 days gave 30 and 100% survival rates, respectively. These results compared with 100% mortality in infected controls and 100% survival among mice treated with amphotericin B. UK-49,858 did not eradicate the fungus from the lungs of surviving animals, while amphotericin B effected sterilization of the lungs in 66% of the survivors.This publication has 2 references indexed in Scilit:
- Activity of UK-49,858, a bis-triazole derivative, against experimental infections with Candida albicans and Trichophyton mentagrophytesAntimicrobial Agents and Chemotherapy, 1985
- Pathogen factors and host factors in murine pulmonary blastomycosisMycopathologia, 1982