Is Xenotransplantability of Human Colon Cancers in SCID Mice Affected by Angiogenic Factors?

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Abstract
Human malignant tumors transplanted in SCID (severe combined immunodeficiency) mice retain their original characteristics, such as histology (1), cytokine production (2,3), karyotype, and sensitivity to anticancer agents. This in vivo system has provided an opportunity to study viable human malignant cells without limitations on material supply. Since Rygaard and Povlsen (4) reported the successful transplantation of human malignant tumors into nude mice, various types of human tumors have been maintained in these animals. Although this system has enabled us to establish certain human malignant tumors as xenografts, only transferable tumors are serially maintained as xenograft tumors. It is not clearly understood what key properties and molecules of donor tumor lead to successful establishment of xenografts.
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