Drug Administration in Hepatic Disease

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Abstract
THE biologic processes that govern the absorption of a drug into the body and its elimination from it are important determinants of its pharmacologic effect and toxicity. Absorption occurs after administration of a drug parenterally or via the gastrointestinal tract, the skin, lung, eye, or other tissues and organs. Each route possesses certain characteristics that control the rate and extent of entry of a drug into the systemic circulation. Drugs are eliminated from the body through the excretion of unchanged drug or through biotransformation to one or more metabolites. Because absorption usually occurs more rapidly than elimination, the processes of . . .