Production of High-potency Cryoprecipitate from Exercised Blood Donors and the Treatment of Hemophilia A with This Material
Open Access
- 1 October 1974
- journal article
- research article
- Published by Oxford University Press (OUP) in American Journal of Clinical Pathology
- Vol. 62 (4) , 496-501
- https://doi.org/10.1093/ajcp/62.4.496
Abstract
This paper describes an investigation in which a higher potency cryoprecipitate was prepared from blood donors immediately following a short period of strenuous muscular exercise. The post-exercise plasma factor VIII activity showed a significant average increase of 71% when compared with the pre-exercise factor VIII activity. Accordingly, cryoprecipitate bags prepared from exercised donors contained an average of 165 units factor VIII compared with an average of 73 units per bag of unexercised cryoprecipitate. When two patients with hemophilia A were treated with exercised cryoprecipitate, the in-vivo factor VIII activity achieved showed average increases of 44.7% and 70.3% when compared with activities produced by an equal number of bags of unexercised cryoprecipitate.Keywords
This publication has 0 references indexed in Scilit: