Proviruses are adjacent to c-myc in some murine leukemia virus-induced lymphomas.
- 1 April 1984
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 81 (7) , 2097-2101
- https://doi.org/10.1073/pnas.81.7.2097
Abstract
Sixty-one murine leukemia virus-induced rat and mouse lymphomas were examined for evidence of proviral insertions adjacent to known oncogenes. Five of these lymphomas were found to have alterations adjacent to c-myc. Two of the lymphomas with altered c-myc sequences were examined in detail. Evidence was obtained showing that the alterations in the c-myc sequences in these 2 lymphomas were the result of proviral integrations. Evidently, lymphomagenesis by murine leukemia viruses can result from insertional mutagenesis of cellular oncogenes.This publication has 26 references indexed in Scilit:
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