(+)-α-( N -1-Phenethyl)Urea Stereospecifically Inhibits Ca 2+ - But Not ADP-Stimulated Mitochondrial Respiration
- 2 July 1976
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 193 (4247) , 66-68
- https://doi.org/10.1126/science.935857
Abstract
The (+) isomer of alpha-(N-1-phenethyl) urea is a moderately potent inhibitor of Ca2+ -stimulated mitochondrial respiration of 45Ca2+ uptake (50 percent inhibition at 0.18 mM) while having no effect on adenosine diphosphate-stimulated respiration; the (-) isomer is without effect up to 4 mM. beta-Phenethylurea does not inhibit with either stimulus. The data support the involvement of a Ca2+ -specific protein in energized mitochondrial Ca2+ uptake.This publication has 11 references indexed in Scilit:
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