Prognostic Factors in Lung Cancer

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Abstract
Non—small-cell lung cancer, which accounts for approximately 75 percent of the cases of lung cancer in the United States, represents a heterogeneous group of cancers, both biologically and histopathologically. Little progress has been made in their therapy over the past decades. In patients with this type of cancer, TNM stage (reflecting the size of the primary tumor, the involvement of regional lymph nodes, and the presence of metastases) is the most important prognostic factor, in that it largely determines treatment.1 , 2 If the patient has no distant metastases, the critical issue in staging is whether the tumor has invaded the mediastinal . . .

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