The Crown-Gall Potato Disk Bioassay as a Primary Screen for Compounds With Antitumor Activity
- 1 September 1981
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 67 (3) , 689-692
- https://doi.org/10.1093/jnci/67.3.689
Abstract
A variety of samples consisting of purified compounds (of various origins) and ethanol extracts from plants were assayed for their activity on the growth and initiation of crown-gall tumors on potato disks. The results demonstrated a high correlation between the ability of these compounds to inhibit the initiation and growth of crown-gall tumors on potato disks and their corresponding activity on the mouse P388 leukemia protocol. Of the 21 compounds tested to date, there were two falsepositives and one false-negative.Keywords
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