INFLUENCE OF FRACTION UNBOUND UPON THE RENAL CLEARANCE OF FUROSEMIDE IN THE ISOLATED PERFUSED RAT-KIDNEY
- 1 January 1985
- journal article
- research article
- Vol. 232 (1) , 263-268
Abstract
The influence of fraction furosemide unbound (varied over a 28-fold range) upon its renal clearance was studied in an isolated perfused rat kidney, while renal function was maintained. Renal clearance and unbound fraction of furosemide were related linearly, the average unbound renal clearance being 3.3 ml min-1. Urine pH and urine flow rate did not influence furosemide renal clearance in the ranges experienced in this study. The results are evidently consistent with those predicted from a consideration of the kinetics of renal excretion.This publication has 12 references indexed in Scilit:
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