Retinal circulation responses to systemic autonomic nerve stimulation

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Abstract
The retinal vessel calibre responses to controlled stimulation of the autonomic nervous system were studied in 10 healthy subjects, using sustained isometric muscle contraction as stimulus. Each subject was studied twice using different mydriatic agents, (1) g.tropicamide 1% a parasympatholytic agent and (2) g. phenylephrine 10% a sympathetic agonist. In the tropicamide study, there was a mean arteriolar constriction of 8.1% (SEM 1.67, p0.05). There was no correlation between the rise in diastolic blood pressure and the degree of retinal vessel constriction, during handgrip contraction in either study. This study has demonstrated a significant association between retinal vessel calibre and systemic autonomic nerve stimulation. The possible mechanisms for the retinal vessel constriction observed in this study are discussed.