Measuring the pO2 Time Behaviour in Tumours as a Valuable Tool in Cancer Therapy

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Abstract
After discussing the manufacture of pO2 microelectrodes, this paper gives some examples of their application in cancer therapy. From one measurement accomplished in the centre of a growing DS carcinosarcoma, it can be seen that with tumours having a mass of 0.8 and 5 g, the mean pO2 level reduces to 8 and 1–2 Torr, respectively. It can be pointed out that – even in very small regions of carcinomatous tissue of some 0.1 g – the pO2 level reduces to such a degree that it clearly stands out against the level found in normal tissue (approximately 40 Torr). This opens up new possibilities for the in vivo discrimination between carcinomatous and normal tissue. It can further beshown that intratumoural pO2 measurements may even yield quantitative statements withrespect to the present stage of a tumour.

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