1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 2: lead optimization affording selective, orally bioavailable compounds with potent Anti-HIV activity

This publication has 12 references indexed in Scilit:

• Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 4: synthesis and structure–Activity relationships for 1-[N-(Methyl)-N-(phenylsulfonyl)amino]-2-(phenyl)-4-(4-(N-(alkyl)-N-(benzyloxycarbonyl)amino)piperidin-1-yl)butanes
  Bioorganic & Medicinal Chemistry Letters, 2001
• 1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 1: discovery of the pyrrolidine scaffold and determination of its stereochemical requirements
  Bioorganic & Medicinal Chemistry Letters, 2001
• Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 1: Discovery and initial structure–activity relationships for 1-amino-2-phenyl-4-(piperidin-1-yl)butanes
  Bioorganic & Medicinal Chemistry Letters, 2001
• Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 2: structure–activity relationships for substituted 2-aryl-1-[ N -(methyl)- N -(phenylsulfonyl)amino]-4-(piperidin-1-yl)butanes
  Bioorganic & Medicinal Chemistry Letters, 2001
• HIV-1 entry – an expanding portal for drug discovery
  Drug Discovery Today, 2000
• Inhibitors of Strand Transfer That Prevent Integration and Inhibit HIV-1 Replication in Cells
  Science, 2000
• A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity
  Proceedings of the National Academy of Sciences, 1999
• Potent suppression of HIV-1 replication in humans by T-20, a peptide inhibitor of gp41-mediated virus entry
  Nature Medicine, 1998
• HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5
  Nature, 1996
• Identification of a major co-receptor for primary isolates of HIV-1
  Nature, 1996