Interaction between serum albumin and mercaptoundecahydrododecaborate ion (an agent for boron-neutron capture therapy of brain tumor). II. Proposal of two interaction models.

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Abstract
Two models were proposed for the reaction between mercaptoundecahydrododecaborate ions [B12H12SH2-] and protein molecules. Both models assume 2-step reactions, the 1st step being different between the 2 models; random- and monogamous-pairing models. Measuring the equilibrium concentrations of protein-ligand complex for many combinations of the borate and protein concentrations, and applying the modified simplex method to the data obtained, a set of parameter values can be found by which the experimental results are best explained. These parameters include the number of active sulfhydryl groups, .alpha., the number of active disulfide groups, .beta., per intact protein molecule, and the equilibrium constants, K1 and K2, for the 1st and 2nd steps.

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