The control of globin and other eukaryotic genes
- 1 January 1982
- journal article
- research article
- Published by Wiley in Journal of Cellular Physiology
- Vol. 113 (S1) , 137-143
- https://doi.org/10.1002/jcp.1041130421
Abstract
The hypothesis is advanced that eukaryotes control different parts of their genomes by the selective use of origins of replication. Replication of a gene from an origin upstream of the gene is postulated to open it for transcription under appropriate circumstances; replication of a gene from an origin downstream of the gene closes it. The applicability of this hypothesis to the control of the human β-globin cluster of genes is considered.Keywords
This publication has 20 references indexed in Scilit:
- Major rearrangement in the human β-globin gene clusterNature, 1981
- The Organization of Repetitive Sequences in Mammalian Globin Gene ClustersPublished by Cold Spring Harbor Laboratory ,1981
- The structure and evolution of the human β-globin gene familyCell, 1980
- Ubiquitous, interspersed repeated sequences in mammalian genomes.Proceedings of the National Academy of Sciences, 1980
- A ubiquitous family of repeated DNA sequences in the human genomeJournal of Molecular Biology, 1979
- Physical mapping of the globin gene deletion in (δβ)° - thalassaemiaGene, 1979
- The structure of the human β-globin gene in β-thalassaemiaNucleic Acids Research, 1979
- Characterisation of deletions which affect the expression of fetal globin genes in manNature, 1979
- Analysis of the β-δ-globin gene loci in normal and hb lepore DNA: Direct determination of gene linkage and intergene distanceCell, 1978
- THE PRESENT STATUS OF THE HETEROGENEITY OF FETAL HEMOGLOBIN IN β‐THALASSEMIA: AN ATTEMPT TO UNIFY SOME OBSERVATIONS IN THALASSEMIA AND RELATED CONDITIONS*Annals of the New York Academy of Sciences, 1974