In-vitro activity of azithromycin compared with other macrolides and oral antibiotics against Salmonella typhi
- 1 January 1990
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 25 (suppl A) , 29-31
- https://doi.org/10.1093/jac/25.suppl_a.29
Abstract
The in-vitro activity of azithromycin against 60 clinical isolates of Salmonella typhi was determined by broth microdilution and compared with eight macrolides, including erythromycin, and with other orally administered antimicrobial agents (ampicillin, amoxycillin, cefaclor, trimethoprim/sulphamethoxazole, chloramphenicol, tetracycline, and ciprofloxacin). Azithromycin was more potent (MIC range 4–16 mg/l; MIC 90 8 mg/l) than erythromycin (MIC range 32- > 128 mg/l; MIC 90 , > 128 mg/l). Of the other macrolides, only rosaramkan showed increased activity against Salm. typhi (MIC range 16–32 mg/l; MIC 90 32 mg/l) when compared with erythromycin. All 60 Salm. typhi were susceptible to ciprofloxacin (MIC < 0.5 mg/l). In 22 isolates, resistance to one or more of the following compounds occurred: ampicillin, amoxycillin, cefaclor, tetracycline, chloramphenicol, trimethoprim/sulphamethoxazole.Keywords
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