Stimulation of Glucose Metabolism in Trichophyton mentagrophytes during Incubation in Increased Carbon Dioxide Tension

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Abstract
SUMMARY: An inducible UDPG pyrophosphorylase (UTP:α-d-glucose-1-phosphate uridyltransferase, EC 2.7.7.9) has been demonstrated in cell-free extracts from Trichophyton mentagrophytes incubated in increasing atmospheric tensions of carbon dioxide. Assays of related enzymes have shown that UDPG pyrophosphorylase is not the only enzyme induced by CO2. Glucose-6-phosphate dehydrogenase (EC 1.1.1.49) and glucose-phosphate isomerase (EC 5.3.1.7) were more strongly stimulated than UDPG pyrophosphorylase. Hexokinase (EC 2.7.1.1), phosphoglucomutase (EC 2.7.5.1) and 6-phosphogluconate dehydrogenase (EC 1.1.1.43) were more weakly stimulated than UDPG pyrophosphorylase. The stimulation of UDPG pyrophosphorylase does not occur as a result of sequential induction.

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