A Highly Enantioselective Intramolecular Heck Reaction with a Monodentate Ligand
- 18 December 2001
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 124 (2) , 184-185
- https://doi.org/10.1021/ja017200a
Abstract
An efficient enantioselective intramolecular Heck reaction of cyclohexadienones, using readily available and modular TADDOL-based mono- and bidentate phosphoramidites as chiral ligands and not requiring any additives, has been developed. Excellent enantioselectivities up to 96% ee are reached for the first time in a Heck reaction with monodentate ligands.Keywords
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