Assembly and Function of Type III Secretory Systems
Top Cited Papers
- 1 October 2000
- journal article
- review article
- Published by Annual Reviews in Annual Review of Microbiology
- Vol. 54 (1) , 735-774
- https://doi.org/10.1146/annurev.micro.54.1.735
Abstract
▪ Abstract Type III secretion systems allow Yersinia spp., Salmonella spp., Shigella spp., Bordetella spp., and Pseudomonas aeruginosa and enteropathogenic Escherichia coli adhering at the surface of a eukaryotic cell to inject bacterial proteins across the two bacterial membranes and the eukaryotic cell membrane to destroy or subvert the target cell. These systems consist of a secretion apparatus, made of ∼25 proteins, and an array of proteins released by this apparatus. Some of these released proteins are “effectors,” which are delivered into the cytosol of the target cell, whereas the others are “translocators,” which help the effectors to cross the membrane of the eukaryotic cell. Most of the effectors act on the cytoskeleton or on intracellular-signaling cascades. A protein injected by the enteropathogenic E. coli serves as a membrane receptor for the docking of the bacterium itself at the surface of the cell. Type III secretion systems also occur in plant pathogens where they are involved both in ca...Keywords
This publication has 194 references indexed in Scilit:
- Visualization of harpin secretion in planta during infection of apple seedlings by Erwinia amylovoraCellular Microbiology, 1999
- Functional analysis of plant disease resistance genes and their downstream effectorsCurrent Opinion in Plant Biology, 1999
- DspA, an essential pathogenicity factor of Erwinia amylovora showing homology with AvrE of Pseudomonas syringae, is secreted via the Hrp secretion pathway in a DspB‐dependent wayMolecular Microbiology, 1997
- ExoU expression by Pseudomonas aeruginosa correlates with acute cytotoxicity and epithelial injuryMolecular Microbiology, 1997
- Calmodulin and the oxidative burst: Harding, S.A., Oh, S-H, and Roberts, D.M. (1997) Transgenic tobacco expressing a foreign calmodulin gene shows an enhanced productions of active oxygen species, EMBO J. 16, 1137–1144Trends in Plant Science, 1997
- Modulation of bacterial entry into epithelial cells by association between vinculin and the Shigella IpaA invasinThe EMBO Journal, 1997
- The Yersinia Yop virulon: a bacterial system for subverting eukaryotic cellsMolecular Microbiology, 1997
- Identification of the YopE and YopH domains required for secretion and internalization into the cytosol of macrophages, using the cyaA gene fusion approach.Proceedings of the National Academy of Sciences, 1995
- Erwinia amylovora hrpN mutants, blocked in harpin synthesis, express a reduced virulence on host plants and elicit variable hypersensitive reactions on tobaccoEuropean Journal of Plant Pathology, 1995
- Bacteria Expressing Avirulence Gene D Produce a Specific Elicitor of the Soybean Hypersensitive ReactionMolecular Plant-Microbe Interactions®, 1990