Effect of Chlorophyll Derivatives and Related Compounds on the Growth of M. tuberculosis

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Abstract
Conclusions Chlorin-e and chlorophyll in in concentrations of .025 and .050% in glycerine broth and Sauton's media inhibited the growth of H-37 and avian tubercle bacilli. Copper chlorin-e, deuteroporphyrin, copper deuteroporphyrin, and pyrroporphyrin sulfonic acid-sodium salt showed no growth retarding effects in concentrations of .025 and .050%. Evidence is presented to suggest that the H-37 tuber-culo-protein of the living bacillus is capable of binding copper chlorin-e. The absorption spectrum of the copper chlorin-e-bacillary protein complex when compared with that of copper chlorin-e-sodium in aqueous solution lends support to the assumption that chemical union between protein and pigment exists.

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