Immunohistochemical Observations of Macrophages and Perisinusoidal Cells in Carbon Tetrachloride-induced Rat Liver Injury.
- 1 January 1993
- journal article
- Published by Japanese Society of Veterinary Science in The Journal of Veterinary Medical Science
- Vol. 55 (6) , 973-977
- https://doi.org/10.1292/jvms.55.973
Abstract
In rat liver injured by carbon tetrachloride, ED-1-positive monocytes and resident macrophages significantly increased in number in damaged perivenular zones on days 2 and 4 after single or double dosing, peaking on day 2 and being two-fold more after the 2nd dosing. ED-2-positive resident macrophages significantly increased in number only on day 4 after the single dosing and on days 2, 4 and 6 after the 2nd dosing with a peak on day 2. A significant increase in number of muscle actin-positive perisinusoidal cells was seen on day 4 and on days 2 and 4 after the 1st and 2nd dosings, respectively, reaching a peak on day 4 and being more remarkable after the 2nd dosing.Keywords
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