Absorption of different amino acids by an intestinal preparation from normal rats and from rats exposed to supralethal X-Irradiation

Publisher Website
Google Scholar
Abstract
Summary Absorption of different amino acids [lysine,α-amino isobutyrate (AIB), methionine, alanine, glycine] was studied in an intestinal in vivo preparation from normal and X-irradiated rats (1 and 3 days after 2000 R). Absorption of amino acids under loading and in presence of other amino acids was also followed. Lysine and AIB absorption follow a saturation kinetics with a maximal velocity of 35 and 85.6 µmoles/min and aK t of 10 and 67 µmoles for lysine and AIB respectively. Interference in absorption exists not only between amino acids of the same class, but also by lysine on neutral amino acids. One day after irradiation, absorption is normal or even enhanced, although active transport appears impaired as indicated by the increase inK t. Three days after exposure, absorption, particularly the active one, is severely depressed. This is indicated by the low Vm and highK t, as well as by the fact that loading has little influence on absorption.

This publication has 19 references indexed in Scilit: