A gene (Neu-1) on chromosome 17 of the mouse affects acid α-glucosidase and codes for neuraminidase
- 1 August 1981
- journal article
- research article
- Published by Hindawi Limited in Genetics Research
- Vol. 38 (1) , 47-55
- https://doi.org/10.1017/s0016672300020395
Abstract
SUMMARY: An electrophoretically detectable variant of acid α-glucosidase has been found in SM/J mice. This variant is attributable to excess sialylation of the enzyme and is determined by a gene, alpha-glucosidase processing,Aglp, on chromosome 17. In addition, as also reported by Potier, Lu Shun Yan & Womack (1979), SM/J mice are relatively deficient in neuraminidase and it appears that the low level of this enzyme in SM/J is determined by an autosomal codominant gene, neuraminidase-1,Neu-1. Preliminary data indicate thatNeu-1is also on chromosome 17. It seems probable that the several processing genesApl, AglpandMap-2which are all closely linked on chromosome 17 are one and the same, a geneNeu-1coding for neuraminidase.This publication has 18 references indexed in Scilit:
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