Polycomponent Ophthalmic Inserts with Polysaccharide Support

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Abstract
Ophthalmic inserts, based on xanthane modified with pilocarpine, adrena line and hydrocortisone have been prepared. The drugs were fixed in the insert by ionic bonds and gel entrapment. The in vitro release rate of pilocarpine de pended on the degree of xanthane modification and on the drug content in the polymer matrix. Inserts show a high ophthalmic tolerance indicating the potential for treatment of glaucoma.