A Genetic Study of Resistance to Thiabendazole and Sodium O-Phenylphenate in Penicillium italicum by the Parasexual Cycle

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Abstract
Mutants of P. italicum resistant to 0.5 mg/l of thiabendazole (TBZ) were obtained only after mutagenizing sensitive conidia. Although mutagenized sensitive conidia did not yield mutants resistant to 7 or 500 mg/l TBZ, such mutants were recovered after mutagenizing conidia from a strain resistant to 0.5 mg/l TBZ. The 3 levels of resistance were termed low (L), intermediate (I), or high (H). Diploids heterozygous for H mutants had H resistance; diploids heterozygous for L or I mutants had L resistance. Resistance to 50 mg/liter of sodium o-phenylphenate (SOPP) was determined by a dominant mutation, and diploids heterozygous for SOPP resistance were resistant. Haploid segregants from 14 diploid strains with different combinations of TBZ and SOPP sensitivity or resistance were genetically analyzed and indicated that L, I and H resistance to TBZ probably results from a mutation in 2 or 3 closely linked loci. Resistance to TBZ or SOPP, 2 mutations for different conidia colors, and 2 mutations for different mutritional deficiencies were assigned to 4 linkage groups.

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