Metabolism of 35S-labelled Antithyroid Drugs in Man
- 3 May 1969
- Vol. 2 (5652) , 290-291
- https://doi.org/10.1136/bmj.2.5652.290
Abstract
Differences in the metabolic fate of antithyroid drugs influence the optimal frequency of administration and their therapeutic efficacy. 35S propylthiouracil differed from the 35S imidazoles (carbimazole and methimazole) in the more rapid absorption and excretion and the shorter biological half-life in the plasma of the former. Renal function may have a more important influence on the biological half-life of the drugs than thyroid status. Further work is required to determine the optimal frequency of administration for each compound.Keywords
This publication has 3 references indexed in Scilit:
- Development of Thyroidal Suppression by Triiodothyronine During Six Months' Treatment of Thyrotoxicosis with Antithyroid DrugsJournal of Clinical Endocrinology & Metabolism, 1967
- The Desulfuration of Thiourea by Thyroid Cytoplasmic Particulate FractionsJournal of Biological Chemistry, 1959
- STUDIES ON THE METABOLISM OF THIOUREA .2. THE METABOLIC FATE OF THIOUREA IN THE THYROID GLAND1950