Histological Sectioning of the Rodent Larynx for Inhalation Toxicity Testing
Open Access
- 1 January 1992
- journal article
- other
- Published by SAGE Publications in Toxicologic Pathology
- Vol. 20 (1) , 118-121
- https://doi.org/10.1177/019262339202000115
Abstract
In rodents, the larynx is a major site of histopathologic alteration following inhalation exposure to particulates, vapors, and aerosols. Specifically, the epithelial lining of a narrowly delineated region on the ventral floor of the larynges of rats and mice appears to be especially vulnerable to inhaled materials, and is recognized as a preferred site for histopathological evaluation in inhalation studies. This site is located at the base of the epiglottis, cranial to the ventral laryngeal diverticulum (ventral pouch). The presence of underlying seromucinous glands is critical for histologic identification of this site. We report a histologic sectioning technique, using the ventral laryngeal diverticulum as the anatomical landmark, to obtain tissue sections from this area of predilection in rats and in mice.Keywords
This publication has 10 references indexed in Scilit:
- Inhalation toxicity studies of cobalt sulfate in F344/N rats and B6C3F1 miceFundamental and Applied Toxicology, 1990
- Histopathology, Urine Mutacenicity, and Bone Marrow Cytocenetics of Mice Exposed Nose-Only to Smoke from Cigarettes that Burn or Heat TobaccoInhalation Toxicology, 1990
- Histologic changes in the respiratory tract induced by inhalation of xenobiotics: Physiologic adaptation or toxicity?Toxicology and Applied Pharmacology, 1989
- Ninety-day inhalation study in rats, comparing smoke from cigarettes that heat tobacco with those that burn tobacco*1Fundamental and Applied Toxicology, 1989
- Comparative Inhalation Study in Rats, Using a Second Prototype of a Cigarette that Heats Rather than Burns TobaccoInhalation Toxicology, 1989
- Atlas of Experimental Toxicological PathologyPublished by Springer Nature ,1987
- Factors affecting the distribution of tobacco smoke-induced lesions in the rodent larynx☆Toxicology Letters, 1981
- Transient epithelial loss in rat larynx after acute exposure to tobacco smokeToxicology Letters, 1980
- Cigarette smoke induced pathology of the rat respiratory tract: A comparison of the effects of the particulate and vapour phasesToxicology, 1980
- Inhalation toxicity studies on cigarette smoke (VII) 6-week comparative experiments using modified flue-cured cigarettes: Histopathology of the conducting airwaysToxicology, 1978