NORFLOXACIN: IN VITRO ACTIVITY COMPARED WITH THAT OF SEVEN OTHER ANTIBACTERIAL AGENTS AGAINST URINARY TRACT PATHOGENS

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Abstract
The minimal inhibitory concentrations (MIC) of norfloxacin, nalidixic acid, ampicillin, amoxycillin/clavulanic acid (4:1), mecillinam, cefaclor, sulfamethoxazole/trimethoprim (20:1) and netilmicin against 435 clinical (human) isolates of bacterial urinary tract pathogens were determined. An agar dilution method was employed. Norfloxacin was the most active agent in the study, on a weight-for-weight basis. The drug was highly active against Enterobacteriaceae. Norfloxacin was more active than netilmicin against Pseudomonas aeruginosa (MIC .ltoreq. 2 mg/l and .ltoreq. 4 mg/l respectively). Norfloxacin was also active against gram-positive bacteria, including enterococci and Staphylococcus saprophyticus (MIC .ltoreq. 4 mg/l). Norfloxacin may well become a useful agent for the oral treatment of urinary tract infection, particularly as a drug for the treatment of infections caused by multiresistant organisms.

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