Meta-Analysis, Decision Analysis, and Cost-Effectiveness Analysis

Abstract
This book is an introduction to three methods of quantitative synthesis—meta-analysis, decision analysis, and cost-effectiveness analysis. These methods are used widely to summarize information in order to guide the formulation of clinical recommendations and guidelines, and in clinical decision-making and health policy. The book gives step-by-step instructions on how to conduct studies that use each of the three methods, emphasizing the need for rigor. Important controversies about the statistical and mathematical theories that underlie the methods are highlighted, and key assumptions are identified. The methods are critically appraised and practices that should be avoided are identified. Despite the time that has elapsed between the last revision in 2000, the book remains a relevant and highly accessible source of information on how to conduct studies that use the three methods.

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