Fatty Acid Binding Proteins—The Evolutionary Crossroads of Inflammatory and Metabolic Responses
Open Access
- 1 September 2004
- journal article
- review article
- Published by Elsevier in Journal of Nutrition
- Vol. 134 (9) , 2464S-2468S
- https://doi.org/10.1093/jn/134.9.2464s
Abstract
Fatty acid binding proteins (FABPs) are members of a highly conserved family of proteins with the task of protecting a cell's delicate lipid balance. Yet they fail when faced with metabolic or inflammatory stress, turning the cytosol into an inhospitable environment with less than ideal outcomes. This review will focus on how FABPs direct lipid traffic and simultaneously control inflammatory and metabolic pathways under the pressures of the Metabolic Syndrome.Keywords
This publication has 60 references indexed in Scilit:
- Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40Nature, 2003
- A central role for JNK in obesity and insulin resistanceNature, 2002
- Selective Cooperation between Fatty Acid Binding Proteins and Peroxisome Proliferator-Activated Receptors in Regulating TranscriptionMolecular and Cellular Biology, 2002
- Dietary polyunsaturated fatty acids and regulation of gene transcriptionCurrent Opinion in Lipidology, 2002
- Different genes, different diabetes: lessons from maturity-onset diabetes of the youngAnnals of Medicine, 2002
- Characterization of the Functional Interaction of Adipocyte Lipid-binding Protein with Hormone-sensitive LipaseJournal of Biological Chemistry, 2001
- Insulin signalling and the regulation of glucose and lipid metabolismNature, 2001
- Prevention of fat-induced insulin resistance by salicylateJournal of Clinical Investigation, 2001
- PPARγ Activation Induces the Expression of the Adipocyte Fatty Acid Binding Protein Gene in Human MonocytesBiochemical and Biophysical Research Communications, 1999
- mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.Genes & Development, 1994