THE INFLUENCE OF THE CENTRAL NERVOUS SYSTEM ON THE TRIPLE RESPONSE OF LEWIS

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Abstract
The flare component of the "triple response" after histamine injection into the skin was measured in 118 patients. There were 75 patients with cerebrovascular disease. In these patients disturbances of sensation in the presence of sensorimotor cortex lesions were associated with an enhanced flare on the contralateral side of the body whereas those due to thalamic or spinothalamic tract lesions were associated with a decreased flare on the contralateral side. Paralysis alone without sensory deficits did not alter the flare. Vasodilatation after injury of the skin is an integral part of the inflammatory reaction, and the modulation of this reaction by the central nervous system suggests that some of the trophic changes and painful syndromes that occur after cerebrovascular accidents may be related to these findings.