A Simple and Stable Silica Gel Support for the Oligodeoxyribonucleotide Synthesis
- 1 July 1986
- journal article
- research article
- Published by Taylor & Francis in Nucleosides, Nucleotides and Nucleic Acids
- Vol. 5 (3) , 325-330
- https://doi.org/10.1080/07328318608069981
Abstract
A simple and efficient synthesis of a solid support with a long chain polyamide spacer has been developed. The spacer was made by successive addition of ethylene-diamine and succinic anhydride. The obtained solid support gives very homogeneous 20 mer oligodeoxyribonucleotides, detected by HPLC and electrophoresis.This publication has 7 references indexed in Scilit:
- An improved syringe technique for the preparation of oligonucleotides of defined sequenceTetrahedron Letters, 1983
- Hindered dialkylamino nucleoside phosphite reagents in the synthesis of two DNA 51-mersJournal of the American Chemical Society, 1983
- An investigation of several deoxynucleoside phosphoramidites useful for synthesizing deoxyoligonucleotidesTetrahedron Letters, 1983
- Syringe method for stepwise chemical synthesis of oligonucleotidesNucleic Acids Research, 1982
- Synthesis of deoxyoligonucleotides on a polymer supportJournal of the American Chemical Society, 1981
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesisTetrahedron Letters, 1981
- Arylsulfonyltetrazoles, new coupling reagents and further improvements in the triester method for the synthesis of deoxyribooligonucleotides1Nucleic Acids Research, 1977