Dose-response effects of ethanol on the sleep of young men.

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Abstract
The dose-response relationship between moderate doses of alcohol and human sleep was studied in 10 healthy young men with electrodes attached for standard sleep recording. Following 1 adaptation night, subjects were seen on 5 occasions with a minimum of 5 nights between each occasion. Subjects consumed a beverage containing either 0.00, 0.25, 0.50, 0.75 or 1.00 g of 95% ethanol/kg body wt producing mean blood alcohol concentrations of 0.000, 0.008, 0.049 and 0.074 mg/100 ml, respectively. Although there was no significant relationship between the absolute amount of rapid eye movement (REM) sleep and dose, there was a linear decline in the amount of phasic REM accumulated in the first 5 h of sleep. Slow wave (stages 3 and 4) sleep in the first 3 h of sleep increased with dose and the latency of sleep onset declined, both effects being linear. There was some evidence of dose-dependent rebound effects in the latter part of the night and of increased disturbance at the high dose level.

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