Effects of tubular secretion and reabsorption on titration curves of tubular transport

Publisher Website
Google Scholar
Abstract
Using standard clearance techniques in the dog with constant rates of urine flow and pH, the tubular transport of four organic acids has been shown to reverse from net secretion at low plasma concentrations to net reabsorption at high. The compounds studied are salicylate, p-hydroxybenzoate, salicylurate and chlorphenol red. The results can not be attributed to an artifact of delay time. This phenomenon can best be interpreted as a consequence of active secretion of a limited capacity and passive back diffusion that does not have a maximal rate. An attempt has been made to evaluate the underlying parameters.

This publication has 0 references indexed in Scilit: