m-trifluoromethyl-?-ethylbenzhydrol: A new enzyme inducer
- 1 January 1978
- journal article
- research article
- Published by Springer Nature in European Journal of Clinical Pharmacology
- Vol. 13 (4) , 299-302
- https://doi.org/10.1007/bf00716366
Abstract
The enzyme inducing effect of m-trifluoromethyl-α-ethylbenzhydrol (RGH-3332) has been studied in man, rat and mouse. In man, RGH-3332 decreased the half-life of antipyrine and tolbutamide and increasedd-glucaric acid excretion. In rat and mouse the half-life of antipyrine was shortened. It was concluded that in all three species man, rat and mouse the liver microsomal drug metabolizing enzyme system was induced by RGH-3332. No side-effects were found on treatment with RGH-3332.Keywords
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