Lyt ANTIGENS ON THE T CELLS SPECIFIC FOR MINOR HISTOCOMPATIBILITY ANTIGENS Suppression by a Lyt-l+2- Regulator

Publisher Website
Google Scholar
Abstract
Mouse T cells involved in the cytotoxic response to minor histocompatibility antigens were typed for Lyt-1 and Lyt-2 phenotype. BALB/c cytotoxic T cells specific for DBA/2 minor H antigens are H-2-restricted cells of the Lyt-1-2+ phenotype; they are derived for Lyt-1-2+ precursor cells that require collaborative interactions with Lyt-1+2- helper T cells. Suppressor T cells that are generated in vitro and whose function is radioresistant are able to inhibit the cytotoxic response to minor H. These inhibitors are Lyt-1+2- cells. The experiments were internally controlled to assess the specificity of the antisera. The cell that inhibits the response to minor H probably differs from the cell that inhibits the response to major H-2 antigens.

This publication has 15 references indexed in Scilit: