Binding of four sulphonamides to human albumin
- 1 January 1976
- journal article
- research article
- Published by Springer Nature in European Journal of Clinical Pharmacology
- Vol. 10 (2) , 139-145
- https://doi.org/10.1007/bf00609473
Abstract
The four sulphonamides studied — furosemide, tolbutamide, sulfafurazole and sulfonamidochlorobenzoic acid — bind to human albumin at the same sites but with decreasing affinity. These sites are also common to other drugs, namely acenocoumarin, chlorophenoxyisobutyric acid, phenylbutazone and warfarin. In plasma, the four sulphonamides considered bind mainly to albumin, but also, at higher concentrations, to globulins, to an extent that increases as their affinity for albumin lessens.This publication has 21 references indexed in Scilit:
- Binding of Sulfonylureas to Serum AlbuminJournal of Pharmaceutical Sciences, 1973
- INCREASING ACTIVITY OF SULFONAMIDES WITH DISPLACING AGENTS: A REVIEWAnnals of the New York Academy of Sciences, 1973
- Effect of phenylbutazone on the binding of vitamin K antagonists to albuminEuropean Journal of Clinical Pharmacology, 1973
- Structure-activity relations. 5. Hydrophobic bonding of sulfonamide drugs with serum albuminJournal of Medicinal Chemistry, 1972
- COMPLICATIONS DURING CLOFIBRATE TREATMENT OF NEPHROTIC-SYNDROME HYPERLIPOPROTEINÆMIAThe Lancet, 1972
- Binding of Sulfonylureas to Serum ProteinsJournal of Pharmaceutical Sciences, 1972
- Interindividual Differences in the Protein Binding of Sulfonamides: The Effect of Disease and Drugs 1,2Acta Pharmacologica et Toxicologica, 1971
- Some Physico‐Chemical Factors Influencing the Binding of Sulfonamides to Human Albumin in vitroActa Pharmacologica et Toxicologica, 1971
- Species differences in the plasma protein binding of desipramineJournal of Pharmacy and Pharmacology, 1968
- The Determination of Enzyme Dissociation ConstantsJournal of the American Chemical Society, 1934