Production of Monoclonal Antibodies againstLegionella pneumophilaSerogroup 1
Open Access
- 1 March 1985
- journal article
- research article
- Published by Wiley in Microbiology and Immunology
- Vol. 29 (3) , 275-284
- https://doi.org/10.1111/j.1348-0421.1985.tb00826.x
Abstract
Four monoclonal antibodies to Legionella pneumophila Philadelphia 1 were produced by the fusion of immunized BALB/c lymphocytes to a murine myeloma cell line. Two (Lpl‐1 and Lpl‐3) of the four monoclonal antibodies reacted with 14 L. pneumophila serogroup 1 strains, and the other (Lpl‐2 and Lpl‐4) reacted with only three out of 20 strains tested. These four monoclonal antibodies did not bind to any strains of L. pneumophila serogroup 2–7 and other Legionella species. In addition, it has been shown that these monoclonal antibodies may be useful not only for subserotyping of L. pneumophila but also for retrospective diagnosis using immunopathological methods.This publication has 49 references indexed in Scilit:
- Legionella longbeachae Species Nova, Another Etiologic Agent of Human PneumoniaAnnals of Internal Medicine, 1981
- Fluoribacter dumoffii (Brenner et al.) comb. nov. and Fluoribacter gormanii (Morris et al.) comb. nov.International Journal of Systematic and Evolutionary Microbiology, 1981
- Interaction of the legionnaires' disease bacterium (legionella pneumophila) with human phagocytes. I. L. pneumophila resists killing by polymorphonuclearleukocytes, antibody, and complementThe Journal of Experimental Medicine, 1981
- Interaction of the legionnaires' disease bacterium (Legionella pneumophila) with human phagocytes. II. Antibody promotes binding of L. pneumophila to monocytes but does not inhibit intracellular multiplication.The Journal of Experimental Medicine, 1981
- Pittsburgh Pneumonia Agent: Direct Isolation from Human Lung TissueThe Journal of Infectious Diseases, 1980
- Legionella bozemanii sp. nov. andLegionella dumoffii sp. nov.: Classification of two additional species ofLegionella associated with human pneumoniaCurrent Microbiology, 1980
- The Rickettsia-like Organisms TATLOCK (1943) and HEBA (1959): Bacteria Phenotypically Similar to but Genetically Distinct from Legionella pneumophila and the WIGA BacteriumAnnals of Internal Medicine, 1980
- Four Serogroups of Legionnaires' Disease Bacteria Defined by Direct ImmunofluorescenceAnnals of Internal Medicine, 1979
- The Diagnosis of Legionnaires' DiseaseAnnals of Internal Medicine, 1978
- Continuous cultures of fused cells secreting antibody of predefined specificityNature, 1975