Competitive inhibition of Asp1-β-amide-Val5-angiotensin II by Sar1-Ile5-Ile8-angiotensin II in cat isolated cardiac muscle and coronary vessels

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Abstract
Interaction of Asp1-β-amide-Val5-angiotensin II with the 8-substituted analogue of Asp1-Ile5-angiotensin II, Sar1-Ile5-Ile8-angiotensin II, has been examined on the isolated perfused heart and isolated papillary muscle of the cat. The constrictor effect of angiotensin in the coronary vessels as well as its positive inotropic effect in the heart muscle have been shown to be competitively inhibited by Sar1-Ile5-Ile8-angiotensin II. The antagonistic potency and the duration of the antagonistic effect of the analogue in both coronary vessels and myocardium have been evaluated separately. The analogue has a higher antagonistic potency in coronary vessels than in heart muscle. The duration of the antagonistic effect of Sar1-Ile5-Ile8-angiotensin II was found to be longer in the heart muscle than in coronary vesesels. The possible mechanism of the antagonistic effect of Sar1-Ile5-Ile8-angiotensin II against Asp1-β-amide-Va15-angiotensin II is discussed.

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